Aim - the expression differences of SCN8A (which encodes type VIII alpha subunit of voltage gated sodium channel) and NDUFC2 (which encodes C2 subunit of Complex I enzyme moxidative phosphorylation) genes were evaluated in paired colorectal cancer (CRC) tissues which was relied on our partial transcriptome analysis data in cancer cell lines. A total of 62 paired tissues of CRC patients (34 male, 28 female) were included in the study. The mRNA levels of SCN8A and NDUFC2 genes were determined by using real-time PCR (qRT-PCR and semiquantitative PCR). SCN8A gene expression level was significantly lower in tumor tissues (p = 0,0128) and in the patients with tbe age below 45 years (p = 0,0049). There were also meaningful relationships between the gender, grade of CRC, tumor location, histopatbological classification, and SCN8A expression. There was no NDUFC2 differential expression. However, the tumors taken from rigbt colon had significantly lower NDUFC2 expression. Conclusion: although the voltage gated sodium channels (VGSCs) and Complex I (Cl) were associated to a number of diseases including different types of cancers, tbe different subunits of Cl and individual members of VGSCs seem to be cancer type-specific in varying proportions.

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