The objective of this study was to investigate the effects of the different extracts (aqueous, ethanol and blended mixture) of Chromolaena odorata leaves mixed with crude petroleum (CP) tainted feed (4 ml/100 g diet) on biochemical indices of Wistar rats. Twenty-five male Wistar rats weighing 140 - 180 g were used for this study. The rats were kept one in a cage. Group A which was the control was allowed diet free of crude oil and were not treated with any of the extracts. Group B were exposed to a diet contaminated with crude oil that contained 4ml of crude oil per 100 gram of animal feed without treatment. Groups C-E were fed with diets contaminated with 4 ml of crude oil per 100 g of feed fed contaminated diets with 4 ml of crude oil per 100 g of feed and treated with 500 mg/Kg-1 bodyweight of aqueous, ethanol and blended mixture of ethanol and aqueous extracts, respectively. The respective extracts and blended mixture were given daily to ihe rats via oral gavage in line with body weights. The study was for duration of twenty-eight days after which the rats were sacrificed under sedation with chloroform. This was followed with collection of blood samples and organs of interest All samples were stored at <$E4~symbol Р roman C> and used within forty eight hour for various biochemical analyses. There were significant decrease in haematologicai indices, liver proteins, oxidative enzymes, and antioxidant enzymes when compare with Group 1. Also, liver function maker enzymes, white blood cells (WBC), and malondialdehyde (MDA) were significantly increased by petroleum intoxication. Significant increase were observed in Hb, PCV, RBC, SO, MO, XO, SOD, CAT, albumin, total protein in the arum, liver and kidney; as against decreases in WBC, AST, ALT, ALP and MDA in rats fed crude petroleum (CP) tainted feed that was treated with C. odorata extract. Conclusion: this study showed that administration of C. odorata leaves extracts to rats prevented health risk associated with crude petroleum toxicity.

  Якщо, ви не знайшли інформацію про автора(ів) публікації, маєте бажання виправити або відобразити більш докладну інформацію про науковців України запрошуємо заповнити "Анкету науковця"