Aim - microRNAs (miRNAs) are small noncoding RNAs that function as oncogene or tumor suppressors. The single nucleotide polymorphisms in miRNAs potentially can alter miRNA-binding sites on target genes as well as affecting miRNAs expression. The present study aimed to evaluate the impact of miR-608 rs4919510 C >> G variant on breast cancer (BC) risk. This case-control study conducted on 160 women with BC and 192 age-matched healthy women. Genotyping of miR-608 rs4919510 was done using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Our findings showed that GC genotype significantly decreased the risk of BC (odds ratio (OR) = 0,49, 95 % confidence interval (CI) 0,28 +- 0,88, p = 0,018) compared to CC genotype. Furthermore the G allele decreased the risk of BC (OR = 0,53, 95 % CI 0,30 - 0,92, p = 0,024). No significant association was found between miR-609 genotypes and clinicopathological characteristics of BC patients (p >> 0,05). Conclusion: our findings indicate that miR-608 polymorphism might be associated with decreased risk of BC in an Iranian subpopulation. Further large-scale studies with different ethnicities are needed to verify our findings.

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