Mechanisms of the effect of adenosine on transmitter release were investigated. Exogenous adenosine reduced transmitter release via P1 receptors. This reduction was not affected by changes in the <$E [ roman Ca sup 2+ ]>, but was abolished by a P1 blocker, teophylline, and <$E roman Ba sup 2+>. The effects of <$E roman Ba sup 2+> ions were suggested to be due to the involvement of <$E roman A sub 2a> receptors. Blockers of the A-type (catechol and 4-aminopyridine) and BK-type (iberiotoxin) potassium channels enhanced transmitter release and abolished the effect of adenosine. The findings suggest a possibility of <$E roman A sub 2a> channels to be coupled to BK and A potassium channels.

  Якщо, ви не знайшли інформацію про автора(ів) публікації, маєте бажання виправити або відобразити більш докладну інформацію про науковців України запрошуємо заповнити "Анкету науковця"