Influences of the cholinergic and adrenergic systems on the mnestic effects of arginine-vasopressin (AVP) were studied in rats (a passive avoidance test and its amnesiaafter electroshock) treated with different pharmaco logical agents. Nootropic effects of AVP decreased after treatment with galantamin and eterofen, but were not significantly changed after treatment with metamyzil and obzidan. Injections of AVP improved realization of the retrievel memory engrams under conditions of pirroksan treatment. Such effects of AVP were also found after ephedrine injections, but with a delay. Thus, our experiments showed that AVP interferes with the development of retrograde amnesia, in particular under the influence of an ct-adrenolitic, pirroksan.

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