The research examined the frequency and nature of carbohydrate metabolism disorders in patients with primary hypothyroidism. In 25,8 % of patients increased glycemic indexes responding to a prediabetes stage were found. In patients with thyroid hypofunction (TG) the presence of insulin resistance (IR) by defined HOMA IR and Саro indexes has been proved. The dependence of IR severity on heaviness of hypothyroidism and BMI has been determined. Differentiated treatment of patients with primary hypothyroidism, obesity and initial carbohydrate metabolism disorders has demonstrated the priority of efficiency of combination therapy with appointed metformin and levothyroxine in comparison with the basic substitution therapy. Appointment of metformin for the treatment of the patients with proven IR contributed to the rapid compensation of hypothyroidism, normalization of carbohydrate metabolism indexes, and it is also preventing the possible development of metabolic syndrome.

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