Immediate implant placement and loading can be done in a compromised bone. Curettage, cleaning of the whole area up to good bone quality and primary stability are the main necessities for success. The effect of local application of scaffold-like preparation rich in growth factors (PRGF) on bone regeneration in artificial defects and the potential effect of humidifying titanium dental implants with liquid PRGF on their osseointegration were investigated. The PRGF formulations were obtained from venous blood of three goats and applied either as a 3D fibrin scaffold (scaffold-like PRGF) in the regeneration of artificial defects or as liquid PRGF via humidifying the implants before their insertion. PRGF can accelerate bone regeneration in artificial defects and improve the osseointegration of titanium dental implants. The stability and healing around implants immediately placed into extraction sockets and augmented with different bone graft materials were evaluated. Comparative analysis of implants subjected to immediate functional loading and immediate nonfunctional loading compared to a conventional loading protocol was made.

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