A considerable decrease of constitutive NO-syntase activity (cNOS) in blood thrombocytes of patients with idiopathic pulmonary hypertension (IPH) is shown. This is the evidence of a decrease of NO synthesis with vaso-dilating properties and an increase of inducible NO-syntase activity (iNOS), that is accompanied by increase of the pool of nitrate-anions (<$E roman NO sub 3 sup ->) and promotes the activation of lipids peroxidation. Activity of <$E roman Ca sup 2+> - dependent cNOS in blood thrombocytes of patients with IPH increases, and the part of <$E roman NO sub 2 sup -> of the stable metabolites pool increases under treatment with diltiazem. This is the evidence of the activation of NO pool production with vaso-dilating properties. Treatment with diltiazem doesn't influence the activity <$E roman Ca sup 2+> - independent iNOS and the <$E roman NO sub 3 sup -> pool.

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