We have studied the humoral immunity changes of students under the influence of physical training. In the course of research we have discovered some adaptation reactions under the influence moderate physical loads. In particular there is a downward trend in serum immunoglobulin level (for all basic immunoglobulin classes: IgG, IgM and IgA). We also have analyzed the influence of moderate physical loads on the level of B-lymphocyte expressing antigen CD72. CD72 molecule is a IgM receptor and a ligand for CD5 molecule located on T-cell and it provides effective contact with T-helpers. Functionally mature B-lymphocyte is the precursor of antibody-forming plasma cells and correspondingly it is the cell factor of humoral specific immunity. The tendency is observed for a slight increase in percentage of cells with CD72+ phenotype in the absence of changes in their absolute number. Thus, we can prove the reference data that intensive physical loads inhibit mainly T-system of immunity and have almost no influence on B-cell link at the initial stage of adaptation process. Adaptation reaction of humoral component of specific immunity during moderate physical load is weak.

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