We demonstrated that EGCG was an effective inhibitor of platelet activation and aggregation. Platelets filtered through carbon lost their ability for ADP-induced aggregation. However platelets that were filtered through the carbon pre-treated with EGCG were able to release their granules in respond on ADP stimulation more effective when compared to platelets filtered through unmodified carbon. Thus we can assume that modification with EGCG inhibits platelet reactivity and protects platelets from activation but such platelets remained intact and be able to respond to the stimulus as ADP. This conclusion is supported by SEM images which demonstrated abscence of activated and adhered plateletys on carbon pre-treated with EGCG. Modification of carbon adsorbents with EGCG can protect platelets from activation and clotting while preserving their functionality during haemoperfusion.

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