Introduction. The purpose of this work was to investigate the composition, in vitro antioxidant and antilipase activity of different types of wine produced in Georgia and to identify the relationship, if any, between anti-lipase activity, polyphenol content and the antioxidant activity of the wines. Materials and methods. Individual polyphenols were separated and quantified by HPLC analysis performed using a liquid chromatograph (Varian Prostar 500, Walnut Creek, California, USA). One unit of lipase activity was defined as that amount of lipase which hydrolyses 1,0 micro equivalent of fatty acid from a triglyceride in one hour at pH 7,2 at 37 <^>oC. Ferric reducing ability of plasma (FRAP) assay was applied in order to determine antioxidant activity. All other methods used are standard biochemical methods. Results and discussion. This study investigated the composition, antioxidant and anti-lipase activity of 6 different wines (Saperavi 2016, Saperavi 2017, Tavkveri 2017, Cabernet Franc 2017, 5. Cabernet Sauvignon 2017 and 6. Rkatsiteli 2017) produced in Georgia. Highest polyphenol content was found in Cabernet Sauvignon 2017 and Cabernet Franc 2017 (1843,13 +- 92,15 and 1650,82 +- 82,50 mg L<^>-1, respectively) while Rkatsiteli 2017 had the lowest polyphenol content (1046,42 +- 52,30 mg L<^>-1). Malvidin-3-O-monoglucoside content, expressed as a percentage of total monoglucosides, ranged from 48,12 to 68,58 %. Cabernet Sauvignon 2017 and Cabernet Franc 2017 had highest antioxidant (FRAP) activity, i.e., 2189,05 +- 109,45 and 1973,09 +- 98,65 mg ascorbic acid equivalents L<^>-1, respectively. Cabernet Sauvignon 2017 and Cabernet Franc 2017 also displayed the highest level of pancreatic lipase inhibitory activity (79,7 and 78,7 % inhibition mL<^>-1 of wine, respectively). Rkatsiteli 2017 and Tavkveri 2017 had the lowest anti-lipase activity (58,1 and 56,6 % inhibition mL<^>-1, respectively). Conclusion. Georgian wines represent natural sources of phytochemicals with high levels of antioxidant and antilipase activity.

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