Transient hyperglycemia in acute cerebrovascular patients and post-stroke fatigue

Delva, I. I.

Post-stroke fatigue (PSF) is a common symptom after acute cerebrovascular events (ACE). The objectives of this study were to identify associations of transient hyperglycemia at hospital admission in acute ACE patients with risk of PSF and certain PSF domains during the first year after ACE occurrence. Material and methods. We enrolled in the study 252 non-diabetic patients with ACE. Acute transient hyperglycemia was defined as blood glucose level more than 6,0 mmol/l at hospital admission. Patients' characteristics had been evaluated at hospital stay, at 1, 3, 6, 9 and 12 months after ACE occurrence. PSF was measured by three self-report questionnaires: fatigue assessment scale, multidimensional fatigue inventory-20 and fatigue severity scale. Results. In multivariate logistic regression analysis acute transient hyperglycemia had significant direct associations with PSF (according to all used scales) as well as with each PSF domain at hospital stay, whereas at 1 month after ACE occurrence these associations were significant only for global, physical and mental PSF domains. In the later time points there were no any associations between acute transient hyperglycemia and PSF. Risk of PSF and PSF physical component during hospital stay directly depends on transient hyperglycemia degree, irrespective of other factors (there were statistical increased risks of PSF between fourth and first quartiles of plasma glucose concentration). Conclusions. 1. Acute transient hyperglycemia at hospital admission in ACE patients was associated with increased risk of global PSF and certain PSF domains only within the first month after ACE occurrence. 2. Risk of global PSF and its physical component at hospital stay directly depends on the level of acute transient hyperglycemia.


	Наукова періодика України		Прикарпатський вісник Наукового товариства імені Шевченка