Purpose. Efficiency of regional resource management improvement based on self-organization and adaptation in multi-agent systems in conditions of uncertainty and dynamic environment. Methodology. The given research studies are based on using system analysis methods in order to choose the directions of modeling regional management processes; simulation modeling and theory of multi-agent systems for agent simulation model for regional resource management development. Findings. Analysis of regional development management features and existing approaches and methods of analysis and decision making in this field was carried out. A structure of simulation agent model for regional resource management was designed. Originality. Simulation agent model for regional resource management was developed, economical self-organization and collective adaptation of model elements with their own interests and decision making process were implemented, which allows flexible decentralized resource management planning in conditions of a dynamic environment. Practical value. The designed model represents methodological basis for creating management decision making tools, which provides development planning and effective regional resource usage.

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