Наукова періодика України | Experimental oncology | ||
Iurchenko N. P. Comprehensive analysis of intratumoral lymphocytes and FOXP3 expression in tumor cells of endometrial cancer / N. P. Iurchenko, N. M. Glushchenko, L. G. Buchynska // Experimental oncology. - 2014. - Vol. 36, № 4. - С. 262-266. - Режим доступу: http://nbuv.gov.ua/UJRN/EOL_2014_36_4_11 Aim - to study the tumor microenvironment (CD4+, CD8+ and FOXP3+ lymphocytes) and FOXP3 expression by tumor cells and correlation of studied parameters with clinical and morphological characteristics of endometrial adenocarcinomas. Tumor samples from 40 patients (mean age 56,9 +- 2,8) with endometrial cancer (EC), who did not receive special treatment before surgery (chemotherapy, radiation therapy and hormontherapy), were investigated. Morphological, immunohis-tochemical methods as well as methods of mathematical statistics were applied in the study. It has been determined that high quantity of FOXP3+ tumor cells and intratumoral CD4+ and CD8+ T-Iymphocytes along with the low content of FOXP3+-lymphocytes is typical for the endometrial adenocarcinomas of high differentiation grade (G1). In poorly differentiated (G3) EC an increase of number of FOXP3+-lymphocytes and decrease of CD4+ and CD8+ lymphocytes in lymphocytic infiltrate have been observed. Moreover, decrease of the content of FOXP3+ tumor ceils has been determined. In EC patients correlation between the following parameters has been detected: proliferative activity and deep invasion of tumor in myometrium (R = 0,74); depth of invasion correlated with the number of the FOXP3+ tumor cells (R = -0,63) and number of CD4+ and CD8+ lymphocytes (R = 0,68 and R = -0,55 respectively) in lymphocytic infiltrate. Thus, results of this study are the evidence of significance of the lymphocytic components of tumor microenvironment and content of FOXP3 expressing tumor cells in EC progression. Conclusion: quantitative changes of tumor microenvironment, such as number of CD4+, CD8+ and FOXP3+ lymphocytes and content of FOXP3+ tumor cells correlate with biological characteristics of EC. Цитованість авторів публікації: Бібліографічний опис для цитування: Iurchenko N. P. Comprehensive analysis of intratumoral lymphocytes and FOXP3 expression in tumor cells of endometrial cancer / N. P. Iurchenko, N. M. Glushchenko, L. G. Buchynska // Experimental oncology. - 2014. - Vol. 36, № 4. - С. 262-266. - Режим доступу: http://nbuv.gov.ua/UJRN/EOL_2014_36_4_11.Додаткова інформація про автора(ів) публікації: (cписок формується автоматично, до списку можуть бути включені персоналії з подібними іменами або однофамільці) Якщо, ви не знайшли інформацію про автора(ів) публікації, маєте бажання виправити або відобразити більш докладну інформацію про науковців України запрошуємо заповнити "Анкету науковця"
|
|
Всі права захищені © Національна бібліотека України імені В. І. Вернадського |